Manchester United will face more Spanish opposition in the form of Real Betis in the Europa League last-16, while Arsenal have been paired with Sporting Lisbon.
Erik ten Hag's side overcame Barcelona 4-3 on aggregate in a thrilling play-off round tie and now encounter another team from LaLiga next month.
Arsenal, who topped their Europa League group to advance directly to this stage, will face Portuguese opponents.
The first leg matches will be played on Thursday March 9, with the return games a week later on March 16.